Characterization of a Proteolytically.pdf (1.57 MB)
0/0

Characterization of a proteolytically stable D-peptide that suppresses herpes simplex virus 1 infection: implications for the development of entry-based antiviral therapy.

Download (1.57 MB)
journal contribution
posted on 06.01.2016 by D. Jaishankar, A.M. Yakoub, A. Bogdanov, T. Valyi-Nagy, D. Shukla
Uncontrolled herpes simplex virus 1 (HSV-1) infection can advance to serious conditions, including corneal blindness or fatal encephalitis. Here, we describe a highly potent anti-HSV-1 peptide (DG2) that inhibits HSV-1 entry into host cells and blocks all aspects of infection. Importantly, DG2 is highly resistant to proteases and shows minimal toxicity, paving the way for prophylactic or therapeutic application of the peptide in vivo.

Categories

Keyword(s)

Funding

This work was supported by NIH award AI105573 (to D.S.), a core grant award (EY001792), and a UIC CCTS TR000050 subaward (to T.V.-N.). Unrestricted support from Research to Prevent Blindness to the Department of Ophthalmology is also acknowledged

History

Publisher Statement

This is the copy of an article published in the Journal of Virology © 2015 American Society for Microbiology.

Publisher

American Society for Microbiology

issn

0022-538X

Issue date

01/02/2015

Exports

Categories

Keyword(s)

Exports