Drastic sensing enhancement using acoustic bubbles for surface-based microfluidic sensors
journal contributionposted on 19.06.2018 by A. De Vellis, D. Gritsenko, Y. Lin, Z. Wu, X. Zhang, Y. Pan, W. Xue, J. Xu
Any type of content formally published in an academic journal, usually following a peer-review process.
There is a high demand for ultrafast biosensors for industrial and public health applications. However, the performance of existing sensors is often limited by the slow mass transport process in traditional pressure-driven microfluidic devices. In this paper we show for the first time, that acoustic microbubbles trapped in prefabricated cavities in a micro-chamber are capable of enhancing fluid sample mixing that results in faster delivery of target species to the sensor surface. We demonstrate a drastic reduction of sensor response time (up to 21.3 fold) for surface-based nanosenors in presence of resonantly actuated microbubbles. The obtained results are valid in a wide pH (4-10) range and agree well with previous studies.