Endocrine Disruptors and Prostate Cancer Risk-REVISED-ENDNOTE.pdf (102.05 kB)
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Endocrine disruptors and prostate cancer risk

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journal contribution
posted on 08.08.2009 by Gail S. Prins
There is increasing evidence both from epidemiology studies and animal models that specific endocrine-disrupting compounds may influence the development or progression of prostate cancer. In large part, these effects appear to be linked primarily to interference with estrogen signaling, either through interacting with estrogen receptors (ERs) or by influencing steroid metabolism and altering estrogen levels within the body. In humans, epidemiologic evidence links specific pesticides, PCBs and inorganic arsenic exposures to elevated prostate cancer risk. Studies in animal models also show augmentation of prostate carcinogenesis with several other environmental estrogenic compounds including cadmium, UV filters and Bisphenol A. Importantly, there appears to be heightened sensitivity of the prostate to these endocrine disruptors during the critical developmental windows including in utero and neonatal time points as well as during puberty. Thus infants and children may be considered a highly susceptible population for ED exposures and increased risk of prostate cancers with aging.

Funding

Funded in part by a grant from the National Institutes of Health, R01 ES015584

History

Publisher Statement

Publisher's Copyright: http://www.endocrinology-journals.org/misc/terms.shtml "Disclaimer. This is not the definitive version of record of this article. This manuscript has been accepted for publication in Endocrine-Related Cancer, but the version presented here has not yet been copy edited, formatted or proofed. Consequently, the Society for Endocrinology accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at DOI: 10.1677/ERC-08-0043. © 2008 Society for Endocrinology."

Publisher

Society for Endocrinology

Language

en_US

issn

1479-6805

Issue date

04/06/2008

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