PB_paper_ethno_vs_random_full_pape revised.pdf (545.24 kB)
0/0

Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis

Download (545.24 kB)
journal contribution
posted on 06.12.2013 by C. Gyllenhaal, M. R. Kadushin, B. Southavong, K. Sydara, S. Bouamanivong, M. Xaiveu, L. T. Xuan, N. T. Hiep, N. V. Hung, P. K. Loc, L. X. Dac, T. Q. Bich, N. M. Cuong, H. M. Ly, H. J. Zhang, S. G. Franzblau, H. Xie, M. C. Riley, B. G. Elkington, H. T. Nguyen, D. P. Waller, C. Y. Ma, P. Tamez, G. T. Tan, J. M. Pezzuto, D. D. Soejarto
Context: Whether natural product drug discovery programs should rely on wild plants collected “randomly” from the natural environment, or whether they should also include plants collected on the basis of use in traditional medicine remains an open question. Objective: This study analyzes whether plants with ethnomedical uses from Vietnam and Laos have a higher hit rate in bioassay testing than plants collected from a national park in Vietnam with the goal of maximizing taxonomic diversity (“random” collection). Materials and Methods: All plants were extracted and subjected to bioassay in the same laboratories. Results of assays of plant collections and plant parts (samples) were scored as active or inactive based on whether any extracts had a positive result in a bioassay. Contingency tables were analyzed using chi-square statistics. Results: Random collections had a higher hit rate than ethnomedical collections, but for samples, ethnomedical plants were more likely to be active. Ethnomedical collections and samples had higher hit rates for tuberculosis, while samples, but not collections, had a higher hit rate for malaria. Little evidence was found to support an advantage for ethnomedical plants in HIV, chemoprevention and cancer bioassays. Plants whose ethnomedical uses directly correlated to a bioassay did not have a significantly higher hit rate than random plants. Discussion: Plants with ethnomedical uses generally had a higher rate of activity in some drug discovery bioassays, but the assays did not directly confirm specific uses. Conclusion: Ethnomedical uses may contribute to a higher rate of activity in drug discovery screening.

Funding

The Vietnam-Laos ICBG is supported by grants administered by the Fogarty International Center, U.S. National Institutes of Health (NIH), with funding supplied by NIH, National Science Foundation and the United States Department of Agriculture, as follows: 1 UO1 TW001015-01; 2 UO1 TW001015-06; 3 UO1 TW 001015-10S1; 3 UO1 TW001015-10S2; 2 UO1 TW001015-11A1.

History

Publisher Statement

Post print version of article may differ from published version. The definitive version is available through Pharmaceutical Biology © 2012 Informa Healthcare. DOI: 10.3109/13880209.2011.634424

Publisher

Informa Healthcare

Language

en_US

issn

1388-0209

Issue date

01/01/2012

Exports

Categories

Exports