1/1
2 files

Evolutionary Constraints Shaping Streptococcus pyogenes-Host Interactions

journal contribution
posted on 27.06.2018 by RV Wilkening, MJ Federle
Research on the Gram-positive human-restricted pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) has long focused on invasive illness, the most severe manifestations of GAS infection. Recent advances in descriptions of molecular mechanisms of GAS virulence, coupled with massive sequencing efforts to isolate genomes, have allowed the field to better understand the molecular and evolutionary changes leading to pandemic strains. These findings suggest that it is necessary to rethink the dogma involving GAS pathogenesis, and that the most productive avenues for research going forward may be investigations into GAS in its 'normal' habitat, the nasopharynx, and its ability to either live with its host in an asymptomatic lifestyle or as an agent of superficial infections. This review will consider these advances, focusing on the natural history of GAS, the evolution of pandemic strains, and novel roles for several key virulence factors that may allow the field to better understand their physiological role.

Categories

Keyword(s)

History

Publisher Statement

This is the author’s version of a work that was accepted for publication in trends in microbiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [Vol #25, Issue #7, (JULY 2017)] DOI: 10.1016/j.tim.2017.01.007

Publisher

Elsevier

Language

en_US

issn

0966-842X

Issue date

01/06/2017

Exports

Categories

Keyword(s)

Exports