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GTPases in intracellular trafficking: an overview.

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journal contribution
posted on 25.05.2011 by Nava Segev
Small GTPases that belong to the ras sub-families of Rab, Arf, and Rho, and the large GTPase dynamin, regulate intracellular trafficking. This issue of Seminars of Cell and Developmental Biology highlights topics regarding mechanisms by which these GTPases regulate the different steps of vesicular transport: vesicle formation, scission, targeting and fusion. In addition, the emerging roles of GTPases in coordination of individual transport steps as well as coordination of intracellular trafficking with other cellular processes are reviewed. Finally, common structures and mechanisms underlying the function of the ras-like GTPases and the importance of their function to human health and disease are discussed.

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Publisher Statement

Post print version of article may differ from published version. The definitive version is available through Elsevier at DOI: 10.1016/j.semcdb.2010.12.004

Publisher

Elsevier

issn

1096-3634

Issue date

01/02/2011

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