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Glycosides, Depression and Suicidal Behaviour: The Role of Glycoside-Linked Proteins

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posted on 26.05.2011 by Gianluca Serafini, Maurizio Pompili, Marco Innamorati, Gloria Giordano, Roberto Tatarelli, David Lester, Paolo Girardi, Yogesh Dwivedi
Nowadays depression and suicide are two of the most important worldwide public health problems. Although their specific molecular mechanisms are still largely unknown, glycosides can play a fundamental role in their pathogenesis. These molecules act presumably through the up-regulation of plasticity-related proteins: probably they can have a presynaptic facilitatory effect, through the activation of several intracellular signaling pathways that include molecules like protein kinase A, Rap-1, cAMP, cADPR and G proteins. These proteins take part in a myriad of brain functions such as cell survival and synaptic plasticity. In depressed suicide victims, it has been found that their activity is strongly decreased, primarily in hippocampus and prefrontal cortex. These studies suggest that glycosides can regulate neuroprotection through Rap-1 and other molecules, and may play a crucial role in the pathophysiology of depression and suicide.

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Publisher Statement

© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). The original version is available through MDPI at DOI: 10.3390/molecules16032688.

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MDPI

Language

en_US

issn

1420-3049

Issue date

23/03/2011

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