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Hematological Abnormalities in Neonatal Necrotizing Enterocolitis

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journal contribution
posted on 22.10.2013 by Rhonnie Song, Girish C. Subbarao, Akhil Maheshwari
Objective: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants born prior to 32 weeks gestation or with a birth weight less than 1500 grams. In this article, we review hematological abnormalities associated with NEC. Methods: A literature search was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies. Results: Thrombocytopenia, disseminated intravascular coagulation, increased or decreased neutrophil counts, and hemolytic anemia are frequent events in NEC. Conclusions: NEC is associated with several hematological abnormalities, which may play a direct or indirect role in the pathogenesis of gut mucosal injury. Some of these abnormalities carry important prognostic information.

Funding

National Institutes of Health award HD059142 (A.M.)

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Publisher Statement

© 2012 Informa Healthcare. Available at http://informahealthcare.com/journal/jmf doi:10.3109/14767058.2012.715005

Publisher

Informa Healthcare

Language

en_US

issn

1476-4954

Issue date

01/10/2012

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