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Hybrid NMR: A Union of Solution- and Solid-State NMR

journal contribution
posted on 19.06.2018 by Pallavi Thiagarajan-Rosenkranz, Adrian W. Draney, Justin L. Lorieau
Hybrid NMR (hdNMR) is a powerful new tool that combines the strengths of solution and solid-state NMR to measure dipolar, chemical shift and quadrupolar tensors in aqueous solution. We introduce the theory of hdNMR and partially randomly oriented (PRO) crystalline hydrogel samples. PRO samples produce randomly oriented spectra with characteristic Pake patterns from the solid-state, yet they maintain the high-resolution dispersion of solution NMR experiments. With new pulse sequences, we show how hdNMR can be used to measure with high precision the 1Hα-13Cα dipolar tensor and carboxylate chemical shift anisotropy tensor of aspartate. These measurements contain detailed information on the distribution of electron density, interatomic distances and the orientation dependence of molecular motion.

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Funding

This work was supported by the University of Illinois at Chicago (UIC) and the Department of Chemistry at UIC

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Copyright @ American Chemical Society

Citation

Thiagarajan-Rosenkranz, P., Draney, A. W. and Lorieau, J. L. Hybrid NMR: A Union of Solution- and Solid-State NMR. Journal of the American Chemical Society. 2017. 139(13): 4715-4723. 10.1021/jacs.6b11402.

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American Chemical Society

Language

en_US

issn

0002-7863

Issue date

13/03/2017

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