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Insulin Resistance and Cognition Among HIV-Infected and HIV-Uninfected Adult Women: The Women’s Interagency HIV Study

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journal contribution
posted on 01.11.2013, 00:00 by Victor Valcour, Pauline Maki, Peter Bacchetti, Kathryn Anastos, Howard Crystal, Mary Young, Wendy J. Mack, Mardge Cohen, Elizabeth T. Golub, Phyllis C. Tien
Cognitive impairment remains prevalent in the era of combination antiretroviral therapy (cART) and may be partially due to comorbidities. We postulated that insulin resistance (IR) is negatively associated with cognitive performance. We completed a cross-sectional analysis among 1547 (1201 HIV+ ) women enrolled in the Women’s Interagency HIV Study (WIHS). We evaluated the association of IR with cognitive measures among all WIHS women with concurrent fasting bloods and cognitive testing [Trails A, Trails B, and Symbol Digit Modalities Test (SDMT)] using multiple linear regression models. A smaller subgroup also completed the Stroop test (n = 1036). IR was estimated using the Homeostasis Model Assessment (HOMA). Higher HOMA was associated with poorer performance on the SDMT, Stroop Color-Naming (SCN) trial, and Stroop interference trial, but remained statistically significant only for the SCN in models adjusting for important factors [b = 3.78 s (95% CI: 0.48–7.08), p = 0.025, for highest vs. lowest quartile of HOMA]. HIV status did not appear to substantially impact the relationship of HOMA with SCN. There was a small but statistically significant association of HOMA and reduced neuropsychological performance on the SCN test in this cohort of women.

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Funding

The study is cofunded by the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute on Deafness and Other Communication Disorders. Funding is also provided by the National Center for Research Resources (UCSF-CTSI Grant UL1 RR024131).

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Publisher Statement

This is a copy of an article published in the AIDS Research and Human Retroviruses © 2012 Copyright Mary Ann Liebert, Inc.; AIDS Research and Human Retroviruses is available online at: http://www.liebertonline.com.

Publisher

Mary Ann Liebert

Language

en_US

issn

0889-2229

Issue date

01/05/2012

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