LPA review BBA with figures.pdf (290.28 kB)

Lysophosphatidic acid (LPA) and its Receptors: Role in Airway Inflammation and Remodeling

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journal contribution
posted on 05.12.2013 by Yutong Zhao, Viswanathan Natarajan
Lysophosphatidic acid (LPA), a simple bioactive phospholipid, is present in biological fluids such as plasma and bronchoalveolar lavage (BAL). It appears to have both pro- and anti-inflammatory role in inflammatory lung diseases. Exogenous LPA promotes inflammatory responses by regulating the expression of chemokines, cytokines, and cytokine receptors in lung epithelial cells. In addition to the modulation of inflammatory responses, LPA regulates cytoskeleton rearrangement and confers protection against lung injury by enhancing lung epithelial cell barrier integrity and remodeling. The biological effects of LPA are mediated through its cell surface G-protein coupled LPA1-7 receptors. The role of LPA receptors in lung fibrosis, asthma, and acute lung injury has been investigated using genetically engineered LPA receptor deficient mice and there appears to be a definitive role for endogenous LPA and its receptors in the pathogenesis of pulmonary inflammatory diseases. This review summarizes recent reports on the role of LPA and its receptors in the regulation of lung epithelial inflammatory responses and remodeling.

Funding

The study was supported by National Institutes of Health HL091916 to YZ and HL P01 98050 to VN.

History

Publisher Statement

NOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, [Vol 1831, Issue 1, (2013)] DOI: 10.1016/j.bbalip.2012.06.014

Citation

Zhao YT, Natarajan V. Lysophosphatidic acid (LPA) and its receptors: Role in airway inflammation and remodeling. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. Jan 2013;1831(1):86-92. doi: 10.1016/j.bbalip.2012.06.014

Publisher

Elsevier

Language

en_US

issn

1388-1981

Issue date

01/01/2013

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