Metabolic dysfunction in obese Hispanic women with PCOS
journal contributionposted on 09.11.2015 by S. Sam, B. Scoccia, S. Yalamanchi, T. Mazzone
Any type of content formally published in an academic journal, usually following a peer-review process.
Study question: Are certain ethnic groups with PCOS at increased risk of metabolic disorders? Summary answer: Obese Hispanic women with PCOS are at increased risk of metabolic disorders compared to age- and BMI-matched obese non-Hispanic white women with PCOS in the United States. What is known already: Ethnic differences in body composition and metabolic risk are well established. Polycystic ovary syndrome (PCOS) is a common disorder in reproductive age women and is associated with high rates of insulin resistance, glucose intolerance anddyslipidemia. Study design, size, duration: A cross-sectional observational study was performed at an Academic Medical Center on 60 reproductive age women with PCOS in the United States. Participants/materials, setting, methods: Fasting blood was obtained from 17 Hispanic, 22 non-Hispanic black and 21 non-Hispanic white women with PCOS who were similar in age and BMI. Anthropometric parameters, insulin, lipid and lipoprotein levels by nuclear magnetic resonance were compared between the 3 groups. Main results and the role of chance: Age and BMI were similar between the groups (P=0.52 for age and P=0.60 for BMI). Hispanic women with PCOS had higher waist to hip ratio (WHR) (P=0.02), HOMA-IR (P=0.03), and a more atherogenic lipid and lipoprotein profile consisting of lower HDL (P=0.02), higher LDL particle number (P=0.02), higher VLDL particle size (P=0.03) and lower LDL (P=0.03) and HDL particle size (P=0.005) compared to non-Hispanic white women. The differences in HDL, HOMA-IR, VLDL and LDL size did not persist after adjustment for WHR while differences in LDL particle number (P=0.04) and HDL size (P=0.01) persisted.