REVISEDMoonprotUpdate101217.pdf (64.07 kB)
0/0

MoonProt 2.0: An expansion and update of the moonlighting proteins database

Download (64.07 kB)
journal contribution
posted on 23.10.2018 by Chang Chen, Shadi Zabad, Haipeng Liu, Wangfei Wang, Constance Jeffery
MoonProt 2.0 (http://moonlightingproteins.org) is an updated, comprehensive and open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins contain two or more physiologically relevant distinct functions performed by a single polypeptide chain. Here, we describe developments in the MoonProt website and database since our previous report in the Database Issue of Nucleic Acids Research. For this V 2.0 release, we expanded the number of proteins annotated to 370 and modified several dozen protein annotations with additional or updated information, including more links to protein structures in the Protein Data Bank, compared with the previous release. The new entries include more examples from humans and several model organisms, more proteins involved in disease, and proteins with different combinations of functions. The updated web interface includes a search function using BLAST to enable users to search the database for proteins that share amino acid sequence similarity with a protein of interest. The updated website also includes additional background information about moonlighting proteins and an expanded list of links to published articles about moonlighting proteins

Categories

Keyword(s)

Funding

This work was supported by a UIC College of Liberal Arts and Sciences Award for Faculty in the Natural Sciences to CJJ

History

Publisher Statement

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Nucleic Acids Research following peer review. The definitive publisher-authenticated version Chen, C., Zabad, S., Liu, H., Wang, W., & Jeffery, C. (2018). MoonProt 2.0: An expansion and update of the moonlighting proteins database. Nucleic Acids Research, 46(D1), D640-D644. is available online at: doi:10.1093/nar/gkx1043

Citation

Chen, C., Zabad, S., Liu, H., Wang, W., & Jeffery, C. (2018). MoonProt 2.0: An expansion and update of the moonlighting proteins database. Nucleic Acids Research, 46(D1), D640-D644. doi:10.1093/nar/gkx1043

Publisher

Oxford University Press

Language

en_US

issn

0305-1048

Issue date

04/01/2018

Exports

Categories

Keyword(s)

Exports