Yu C et al Proposed mechanism for lipoprotein remodelling in the brain_BBA2010.pdf (566.2 kB)

Proposed mechanism for lipoprotein remodelling in the brain

Download (566.2 kB)
journal contribution
posted on 10.01.2011, 00:00 by Chunjiang Yu, Katherine L. Youmans, Mary J. LaDu
Lipoprotein remodelling in the periphery has been extensively studied. For example, the processing of nascent apoAI particles to cholesterol-loaded HDL lipoproteins during reverse cholesterol transport involves a series of enzymes, transporters in peripheral tissue, as well as other apolipoproteins and lipoproteins. These extensive modifications and interconversions are well defined. Here, we present the hypothesis that a similar process occurs within the blood brain barrier (BBB) via glia-secreted lipid-poor apoE particles undergoing remodelling to become mature central nervous system (CNS) lipoproteins. We further pose several pressing issues and future directions for the study of lipoproteins in the brain.

Categories

Keywords

History

Publisher Statement

Postprint version of article may differ from published version. The definitive version is available through Elsevier at DOI: 10.1016/j.bbalip.2010.05.001

Publisher

Elsevier

Language

en_US

issn

1388-1981

Issue date

01/08/2010

Exports

Categories

Keywords

Exports