Renal Cell Carcinoma with Isolated Lymph Node Involvement- Long-term Natural History and Predictors of Oncologic Outcomes Following Surgical Resection.pdf (440.74 kB)

Renal Cell Carcinoma with Isolated Lymph Node Involvement: Long-term Natural History and Predictors of Oncologic Outcomes Following Surgical Resection

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journal contribution
posted on 27.06.2018 by Boris Gershman, Daniel M. Moreira, R. Houston Thompson, Stephen A. Boorjian, CM Lohse, BA Costello, JC Cheville, BC Leibovich
Background: Renal cell carcinoma (RCC) with isolated lymph node (LN) involvement has historically been associated with poor prognosis. However, a subset of patients may experience long-term survival. Objective: To examine the natural history of RCC with isolated LN involvement following surgical resection with long-term follow-up, and to evaluate clinicopathologic features associated with disease progression and survival. Design, setting, and participants: A total of 138 patients with isolated pN1M0 RCC underwent partial or radical nephrectomy and LN dissection from 1980 to 2010. Intervention: Partial or radical nephrectomy with LN dissection. Outcome measurements and statistical analysis: Metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS) were estimated using the Kaplan-Meier method. Associations between clinicopathologic features and oncologic outcomes were evaluated using Cox regression models. Results and limitations: Median follow-up among survivors was 8.5 yr. The 5-yr and 10yr MFS, CSS, and OS rates were 16% and 15%, 26% and 21%, and 25% and 15%, respectively. The median time to development of metastases was only 4.2 mo. On multivariable analysis, symptoms at presentation (hazard ratio [HR] 2.40; p = 0.03), inferior vena cava tumor thrombus (HR 1.99; p = 0.003), clear cell (HR 2.21; p = 0.01) and collecting duct/not otherwise specified (HR 4.28; p < 0.001) histologic subtypes, pT4 stage (HR 2.64; p = 0.005), and coagulative tumor necrosis (HR 2.51; p < 0.001) were independently associated with development of metastases. MFS rates at 1 yr after surgery were 71%, 63%, 33%, and 7% for patients with one, two, three, and four to five adverse features, respectively. Limitations include surgical selection bias. Conclusions: Although isolated pN1 disease portends a poor prognosis, a small subset of patients experience durable long-term survival after surgical resection of isolated lymphatic metastases. Adverse prognostic features may enhance patient risk stratification and facilitate multimodal management approaches. Patient summary: Although isolated lymph node metastases portend a poor prognosis, a small subset of patients experience long-term survival following surgical resection. (C) 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.


Publisher Statement

This is the author’s version of a work that was accepted for publication in European Urology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [Vol #72, Issue #2, (AUG 2017)] DOI: 10.1016/j.eururo.2016.12.027





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