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Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.

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posted on 02.08.2016 by Daghfous G, Green WW, Simon Alford, Zielinski BS, Dubuc R
Sensorimotor transformation is one of the most fundamental and ubiquitous functions of the central nervous system (CNS). Although the general organization of the locomotor neural circuitry is relatively well understood, less is known about its activation by sensory inputs and its modulation. Utilizing the lamprey model, a detailed understanding of sensorimotor integration in vertebrates is emerging. In this article, we explore how the vertebrate CNS integrates sensory signals to generate motor behavior by examining the pathways and neural mechanisms involved in the transformation of cutaneous and olfactory inputs into motor output in the lamprey. We then review how 5-hydroxytryptamine (5-HT) acts on these systems by modulating both sensory inputs and motor output. A comprehensive review of this fundamental topic should provide a useful framework in the fields of motor control, sensorimotor integration and neuromodulation.

Funding

We acknowledge the support of the Great Lakes Fishery Commission over the years, as group grants to BZ and RD (GLFC, 54011, 54021, 54035). Group Grants provide the necessary conditions to promote in-depth reviews of this kind. This work was also supported by a grant to RD from the Natural Sciences and Engineering Research Council of Canada (NSERC, 217435), a grant from the Canadian Institutes of Health Research (CIHR, 15129) and a group grant from the Fonds de Recherche du Québec - Santé (FRQS, 5249).

History

Publisher Statement

This is a copy of an article published in Frontiers in Neural Circuits. © 2016 Frontiers Media Publications. © 2016 Daghfous, Green, Alford, Zielinski and Dubuc.

Publisher

Frontiers Media

Language

en_US

Issue date

22/03/2016

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