Retina Final version March 2010.pdf (319.22 kB)
0/0

Structural and Functional Characteristics in Carriers of X-Linked Retinitis Pigmentosa with a Tapetal-Like Reflex

Download (319.22 kB)
journal contribution
posted on 20.08.2012 by Mohamed A. Genead, Gerald A. Fishman, Martin Lindeman
Purpose: to identify the functional and structural characteristics in three female obligate carriers of X-linked retinitis pigmentosa (XLRP) from the same family by using spectraldomain OCT (SD-OCT), fundus autofluorescence (FAF), and microperimetry (MP). Methods: Three female obligate carriers with a tapetal-like reflex (TLR), 21, 49, and 57 years of age, from a single family of XLRP that was seen in the ophthalmology department at the University of Illinois at Chicago, were enrolled in the study. All carriers underwent a complete ophthalmic examination. SD-OCT measurements, a macular MP exam, and FAF testing were performed. Results: The SD-OCT exam in all three carriers showed a normal retinal micro-structure and thickness. Microperimeter testing showed subnormal retinal sensitivity in the areas of the TLR. FAF exam showed the presence of speckled areas of enhanced AF. Conclusions: Our study demonstrates that the carriers of XLRP with a TLR can show an enhanced reflectance on infrared images, abnormal autofluorescence properties, elevated retinal thresholds, and a normal retinal morphology within the posterior pole on SD-OCT testing

Categories

Keyword(s)

Funding

Supported by funds from the Foundation Fighting Blindness, Owings Mills, Maryland; Grant Healthcare Foundation, Lake Forest, Illinois; NIH core grant EYO1792; and an unrestricted departmental grant from Research to Prevent Blindness.

History

Publisher Statement

Post print version of article may differ from published version. The definitive version is available through Lippincott, Williams & Wilkins at DOI: 10.1097/IAE.0b013e3181dde629

Publisher

Lippincott, Williams & Wilkins

Language

en_US

issn

1539-2864

Issue date

01/01/2010

Exports

Categories

Keyword(s)

Exports