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The effects of amygdala and cortical inactivation on taste neophobia

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journal contribution
posted on 20.11.2018 by Jian-You Lin, Joe Arthurs, Steve Reilley
The current study examined the effects of transient inactivation of the basolateral amygdala (BLA; Experiment 1) and gustatory cortex (GC; Experiment 2) on the expression of taste neophobia and its recovery. We found that inactivation (induced by infusions of baclofen/muscimol) of each structure before exposure to a novel saccharin (0.5%) solution elevated intake on Trial 1 (i.e., taste neophobia was attenuated) and, surprisingly, decreased intake on Trial 2. It seems unlikely that this intake reduction on Trial 2 can be attributed to taste aversion learning caused by drug infusions because in the subsequent experiments with the same set of the implanted animals, the rats did not decrease intake when baclofen/muscimol was infused after taste presentation on Trial 1. The latter result suggests that BLA or GC inactivation that attenuates taste neophobia may also impair memory consolidation of a safe taste experience.

Funding

This work was supported by grants DC06456 from the National Institute of Deafness and Other Communication Disorders. Joe Arthurs is now at the Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

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Citation

Lin, J. Y., Arthurs, J., & Reilly, S. (2018). The effects of amygdala and cortical inactivation on taste neophobia. Neurobiology of Learning and Memory, 155, 322-329. doi:10.1016/j.nlm.2018.08.021

Publisher

Elsevier

Language

en

issn

1074-7427

Issue date

01/08/2018

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