Total Synthesis of Selaginpulvilin.pdf (600.61 kB)

Total Synthesis of Selaginpulvilin C and D Relying on in Situ Formation of Arynes and Their Hydrogenation

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posted on 20.12.2017 by Daesung Lee, Rajdip Karmakar
The total syntheses of selaginpulvilins C and D is described. The key strategy for the construction of the core fluorene moiety involves in situ formation of an aryne intermediate followed by its formal hydrogenation. The precursor tetraynes that undergo aromatization via hexadehydro Diels-Alder reaction were prepared from readily available building blocks through typical alkyne coupling reactions.

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12b. The mass spectrometry facility at UIUC is great-ly acknowledged.

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This is a copy of an article published in the Total Synthesis of Selaginpulvilin C and D Relying on in Situ Formation of Arynes and Their Hydrogenation © 2016 American Chemical Society

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American Chemical Society

issn

15237060

Issue date

02/12/2016

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