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Vitamin D and Immune Response: Implications for Prostate Cancer in African Americans.

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journal contribution
posted on 13.06.2016 by K Batai, AB Murphy, L Nonn, RA Kittles
Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associated with advanced stage and higher tumor grade and mortality, while its association with overall PCa risk is inconsistent. Vitamin D deficiency is also more common in AAs than EAs, and the difference in serum vitamin D levels may help explain the PCa disparities. However, the role of vitamin D in aggressive PCa in AAs is not well explored. Studies demonstrated that the active form of vitamin D, 1,25-dihydroxyvitamin D, has anti-inflammatory effects by mediating immune-related gene expression in prostate tissue. Inflammation also plays an important role in PCa pathogenesis and progression, and expression of immune-related genes in PCa tissues differs significantly between AAs and EAs. Unfortunately, the evidence linking vitamin D and immune response in relation to PCa is still scarce. This relationship should be further explored at a genomic level in AA populations that are at high risk for vitamin D deficiency and fatal PCa.

Funding

The authors would like to acknowledge the support from the National  Institutes of Health (1R01MD007105-01 and P50CA090386), the U.S. Department of Defense (W81XWH-10-1-0532), and the Veterans Health Administration (1IK2 CX000926-01).

History

Publisher Statement

This is a copy of an article published in Frontiers in Immunology © 2016 Frontiers Media Publications.

Publisher

Frontiers Media

Language

en_US

Issue date

22/02/2016

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