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A backward procedure for change-point detection with applications to copy number variation detection

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posted on 22.03.2021, 17:16 by S Jun Shin, Y Wu, N Hao
© 2020 Statistical Society of Canada / Société statistique du Canada Change-point detection regains much attention recently for analyzing array or sequencing data for copy number variation (CNV) detection. In such applications, the true signals are typically very short and buried in the long data sequence, which makes it challenging to identify the variations efficiently and accurately. In this article, we propose a new change-point detection method, a backward procedure, which is not only fast and simple enough to exploit high-dimensional data but also performs very well for detecting short signals. Although motivated by CNV detection, the backward procedure is generally applicable to assorted change-point problems that arise in a variety of scientific applications. It is illustrated by both simulated and real CNV data that the backward detection has clear advantages over other competing methods, especially when the true signal is short. The Canadian Journal of Statistics 48: 366–385; 2020 © 2020 Statistical Society of Canada.

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Publisher Statement

This is the pre-peer reviewed version of the following article: Jun Shin, S., Wu, Y.Hao, N. (2020). A backward procedure for change-point detection with applications to copy number variation detection. Canadian Journal of Statistics, 48(3), 366-385., which has been published in final form at https://doi.org/10.1002/cjs.11535. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Citation

Jun Shin, S., Wu, Y.Hao, N. (2020). A backward procedure for change-point detection with applications to copy number variation detection. Canadian Journal of Statistics, 48(3), 366-385. https://doi.org/10.1002/cjs.11535

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Wiley

Language

en

issn

0319-5724

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