Piptocoma-rufescens_Post-review_TetLett_082313.pdf (238.91 kB)
Download fileA cytotoxic dimeric furanoheliangolide from Piptocoma rufescens
journal contribution
posted on 2013-12-19, 00:00 authored by Yulin Ren, Francisco Jiménez, Ricardo García, Milciades Mejía, Heebyung Chai, Norman R. Farnsworth, Djaja D. Soejarto, A. Douglas KinghornA new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was
isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. Its
structure was determined by analysis of its spectroscopic data, with the absolute configuration
being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is
proposed. This compound showed potent cytotoxicity with an IC50 value of 150 nM, when tested
against HT-29 human colon cancer cells.