A cytotoxic dimeric furanoheliangolide from Piptocoma rufescens
journal contributionposted on 2013-12-19, 00:00 authored by Yulin Ren, Francisco Jiménez, Ricardo García, Milciades Mejía, Heebyung Chai, Norman R. Farnsworth, Djaja D. Soejarto, A. Douglas Kinghorn
A new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. Its structure was determined by analysis of its spectroscopic data, with the absolute configuration being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is proposed. This compound showed potent cytotoxicity with an IC50 value of 150 nM, when tested against HT-29 human colon cancer cells.