Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation
journal contributionposted on 2011-06-01, 00:00 authored by Asha S. Eapen, Amsaveni Ramachandran, Jitesh Pratap, Anne George
DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway. Copyright © 2011 S. Karger AG, Basel
This work was supported by National Institutes of Health Grant DE 11657 and by the Brodie Endowment Fund.
Publisher StatementPost print version of article may differ from published version. The definitive version is available through Karger at DOI: 10.1159/000324258 [http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000324258]. © 2011 S. Karger AG, Basel