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Anti-Microbial Activity of Aliphatic Alcohols from Chinese Black Cardamom (Amomum tsao-ko) against Mycobacterium tuberculosis H37Rv

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posted on 2023-03-14, 21:29 authored by So Young Lee, Gauri S. Shetye, So-Ri Son, Hyun LeeHyun Lee, Larry L. Klein, Jeffrey K. Yoshihara, Rui Ma, Scott FranzblauScott Franzblau, Sang Hyun ChoSang Hyun Cho, Dae Sik Jang
The fruits of Amomun tsao-ko (Chinese black cardamom; Zingiberaceae) contain an abundance of essential oils, which have previously demonstrated significant antimicrobial activity. In our preliminary search for natural anti-tuberculosis agents, an acetone extract of A. tsao-ko (AAE) exhibited strong antibacterial activity against Mycobacterium tuberculosis H37Rv. Therefore, the aim of this study was to find the principal compounds in an AAE against M. tuberculosis. Nine aliphatic compounds (1–9) including a new compound (1, tsaokol B) and a new natural unsaturated aliphatic diester (6), together with three acyclic terpenoids (10–12), were isolated from an AAE by repetitive chromatography. The structures of the isolates were determined by spectroscopic data analysis. All isolates were evaluated for activity against M. tuberculosis H37Rv. Isolated compounds 1–6, and 11 had MICs ranging from 0.6–89 µg/mL. In contrast, compounds 7 to 10, and 12 had MICs that were >100 µg/mL. Tsaokol A (3) was the most active compound with MICs of 0.6 µg/mL and 1.4 µg/mL, respectively, against replicating and nonreplicating M. tuberculosis. These results are the first to illustrate the potency of tsaokol A (3) as a natural drug candidate with good selectivity for treating tuberculosis.

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Citation

Lee, S. Y., Shetye, G. S., Son, S. R., Lee, H., Klein, L. L., Yoshihara, J. K., Ma, R., Franzblau, S. G., Cho, S.Jang, D. S. (2023). Anti-Microbial Activity of Aliphatic Alcohols from Chinese Black Cardamom (Amomum tsao-ko) against Mycobacterium tuberculosis H37Rv. Plants, 12(1), 34-. https://doi.org/10.3390/plants12010034

Publisher

MDPI

Language

en

issn

2223-7747