Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea
journal contributionposted on 2022-02-04, 19:31 authored by Duc Danh Cao, Thi Thanh Van Trinh, Huong Doan Thi Mai, Van Nam Vu, Hong Minh Le, Quyen Vu Thi, Mai Anh Nguyen, Thu Trang Duong, Dang Thach Tran, Van Minh Chau, Rui Ma, Gauri Shetye, Sang Hyun ChoSang Hyun Cho, Brian MurphyBrian Murphy, Van Cuong Pham
Three new lavandulylated flavonoids, (2S,2''S)-6-lavandulyl-7,4'-dimethoxy-5,2'-dihydroxylflavanone (1), (2S,2''S)-6-lavandulyl-5,7,2',4'-tetrahydroxylflavanone (2), and (2''S)-5'-lavandulyl-2'-methoxy-2,4,4',6'-tetrahydroxylchalcone (3), along with seven known compounds 4-10 were isolated from culture broth of Streptomyces sp. G248. Their structures were established by spectroscopic data analysis, including 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of 1-3 were resolved by comparison of their experimental and calculated electronic circular dichroism spectra. Compounds 1-3 exhibited remarkable antimicrobial activity. Whereas, two known compounds 4 and 5 exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv with minimum inhibitory concentration (MIC) values of 6.0 µg/mL and 11.1 µg/mL, respectively.
Enhancing basic and translational TB research in northern Vietnam | Funder: National Institutes of Health (Fogarty International Center) | Grant ID: D43TW010530
CitationCao, D. D., Trinh, T. T. V., Mai, H. D. T., Vu, V. N., Le, H. M., Thi, Q. V., Nguyen, M. A., Duong, T. T., Tran, D. T., Chau, V. M., Ma, R., Shetye, G., Cho, S., Murphy, B. T.Pham, V. C. (2019). Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea. Marine Drugs, 17(9), 529-. https://doi.org/10.3390/md17090529
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Rare DiseasesactinomyceteStreptomycesflavonoidanti-tuberculosisanti-microbialcytotoxicityAnimalsAntibiotics, AntitubercularCell Line, TumorCircular DichroismFlavonoidsMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular StructureMycobacterium tuberculosisPoriferaSpectrometry, Mass, Electrospray IonizationVietnamMedicinal & Biomolecular ChemistryPhysical Chemistry (incl. Structural)Pharmacology and Pharmaceutical Sciences