University of Illinois at Chicago
Browse
Aqueous and Vitreous Penetration of Linezolid.pdf (298.91 kB)

Aqueous and Vitreous Penetration of Linezolid and Levofloxacin After Oral Administration

Download (298.91 kB)
journal contribution
posted on 2011-05-27, 00:00 authored by Jomy M. George, Richard Fiscella, Michael Blair, Keith Rodvold, Lawrence Ulanski, John Stokes, Norman Blair, Laura Pontiggia
Purpose: To evaluate the time course of drug concentrations achieved in aqueous (AQ), vitreous (V), and serum (S) compartments after oral administration of linezolid and levofloxacin. Design: Randomized, clinical trial. Methods: Settings: Clinical practice. Patient population: Sixteen patients (16 eyes) undergoing vitrectomy who had not had a prior pars plana vitrectomy in the study eye were randomly assigned to one of 4 groups. Intervention: AQ, V, and S samples were obtained from all subjects after single concomitant doses of linezolid 600mg and levofloxacin 750mg between 1 and 12 h before the procedure: group A - 1-3 h; group B - 3-6 h; group C - 6-9 h; group D - 9-12 h. Main outcome measures: AQ, V, and S concentrations of linezolid and levofloxacin. Results: Overall mean concentrations +/- standard deviation (mu g/mL) achieved by linezolid in AQ, V, and S compartments were 3.32 +/- 2.06, 2.98 +/- 1.87, and 7.91 +/- 3.94, respectively. Overall mean concentrations +/- standard deviation (mu g/mL) achieved by levofloxacin in AQ, V, and S compartments were 2.19 +/- 1.92, 1.95 +/- 1.27, and 7.38 +/- 3.47, respectively. Conclusions: Single concomitant doses of linezolid and levofloxacin achieved AQ and V concentrations above the minimum inhibitory concentration for 90% of common ocular gram-positive and gram-negative pathogens up to 12 h after administration. The combination of linezolid and levofloxacin represents a viable option for the prophylaxis and management of endophthalmitis.

History

Publisher Statement

This is a copy of an article published in the Journal of Ocular Pharmacology and Therapeutics © 2010 [copyright Mary Ann Liebert, Inc.]; Journal of Ocular Pharmacology and Therapeutics is available online at: http://www.liebertonline.com. DOI: 10.1089/jop.2010.0022

Publisher

Mary Ann Liebert

Language

  • en_US

issn

1080-7683

Issue date

2010-12-01

Usage metrics

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC