Associations Between Serum Vitamin D.pdf (504.7 kB)
Download file

Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy.

Download (504.7 kB)
journal contribution
posted on 11.10.2016, 00:00 authored by YA Nyame, AB Murphy, DK Bowen, G Jordan, K Batai, M Dixon, CM Hollowell, S Kielb, JJ Meeks, PH Gann, V Macias, A Kajdacsy-Balla, WJ Catalona, R Kittles
Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low- or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study.

Funding

Supported by a grant from the US Department of Defense W81XWH-10-1- 0532 pd22E (A.B.M.), and the following National Institutes of Health grants: 1R01MD007105-01 (R.K.); IK2CX000926-01 (A.B.M.), and P50 CA090386-10S1 (W.J.C.).

History

Publisher Statement

This is a copy of an article published in the Journal of Clinical Oncology © 2016 American Society of Clinical Oncology Publications.

Publisher

American Society of Clinical Oncology

Language

en_US

issn

0732-183X

Issue date

30/04/2016

Usage metrics

Categories

Keywords

Exports