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Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases.

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posted on 2016-08-03, 00:00 authored by DD Metcalfe, R Pawankar, Steven J. Ackerman, C Akin, F Clayton, FH Falcone, GJ Gleich, AM Irani, MW Johansson, AD Klion, KM Leiferman, F Levi-Schaffer, G Nilsson, Y Okayama, C Prussin, JT Schroeder, LB Schwartz, HU Simon, AF Walls, M Triggiani
Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.

Funding

DDM are ADK are supported by the Division of Intramural Research of NIAID/NIH. SJA is supported in part by research grants from the FDA (R01FD004086), NIH (R21HL118588), American Partnership for Eosinophilic Disorders (APFED), and University of Illinois, Chicago. MWJ is mainly supported by research grants from the NIH (P01 HL088594 and 1U10 HL109168 [PI: N. N. Jarjour]).

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Publisher Statement

This is a copy of an article published in the World Allergy Organization Journal © 2016 BioMed Central Publications. © 2016 Metcalfe et al.

Publisher

BioMed Central

Language

  • en_US

issn

1939-4551

Issue date

2016-02-11

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