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CD44(high) alveolar type II cells show stem cell properties during steady-state alveolar homeostasis

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journal contribution
posted on 27.06.2018, 00:00 by Q Chen, VS Kumar, J Finn, DH Jiang, JR Liang, YY Zhao, YR Liu
The alveolar epithelium is composed of type I cells covering most of the gas-blood exchange surface and type II cells secreting surfactant that lowers surface tension of alveoli to prevent alveolar collapse. Here, we have identified a subgroup of type II cells expressing a higher level of cell surface molecule CD44 (CD44(high) type II cells) that composed similar to 3% of total type II cells in 5-10-wk-old mice. These cells were preferentially apposed to lung capillaries. They displayed a higher proliferation rate and augmented differentiation capacity into type I cells and the ability to form alveolar organoids compared with CD44(low) type II cells. Moreover, in aged mice, 18-24 mo old, the percentage of CD44(high) type II cells among all type II cells was increased, but these cells showed decreased progenitor properties. Thus CD44(high) type II cells likely represent a type II cell subpopulation important for constitutive regulation of alveolar homeostasis.


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© 2011 American Psychological Association. This article may not exactly replicate the final version published in the APA journal. It is not the copy of record. The original publication is available at; DOI: 10.1152/ajplung.00564.2016


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