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CEPsh glia development is not required for general AWC identity or AWC asymmetry

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posted on 2023-05-02, 20:03 authored by Rui Xiong, Yi-Wen Hsieh, Chiou-Fen ChuangChiou-Fen Chuang
The Caenorhabditis elegans VAB-3/Pax6 homeodomain protein was previously shown to play a role in both the development of cephalic sheath (CEPsh) glia and asymmetric differentiation of AWC olfactory neuron subtypes AWC ON /AWC OFF . Here we show that vab-3 is not required for the specification of general AWC identity. We also show that some vab-3 mutant alleles with defective CEPsh glia development displayed wild-type AWC asymmetry. These results suggest that vab-3 has separable roles in CEPsh glia development and AWC asymmetry. Together, our results suggest that general AWC identity and AWC asymmetry are not dependent on the development of CEPsh glia.

Funding

Specification of Stochastic Left-Right Asymmetric Neuronal Fates in C. Elegans | Funder: National Institutes of Health (National Institute of General Medical Sciences) | Grant ID: R01GM098026

History

Citation

Xiong, R., Hsieh, Y. -W.Chuang, C. -F. (2022). CEPsh glia development is not required for general AWC identity or AWC asymmetry. microPublication Biology, 2022, 10.17912/micropub.biology.000636-. https://doi.org/10.17912/micropub.biology.000636

Publisher

Caltech Library

Language

  • en

issn

2578-9430

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