Chemokine Receptors in Epithelial Ovarian Cancer
journal contributionposted on 2016-04-04, 00:00 authored by Goda G Muralidhar, Maria V Barbolina
Ovarian carcinoma is the deadliest gynecologic malignancy with very poor rate of survival, and it is characterized by the presence of vast incurable peritoneal metastasis. Studies of the role of chemokine receptors, a family of proteins belonging to the group of G protein-coupled receptors, in ovarian carcinoma strongly placed this family of membrane receptors as major regulators of progression of this malignancy. In this review, we will discuss the roles that chemokine-receptor interactions play to support angiogenesis, cell proliferation, migration, adhesion, invasion, metastasis, and immune evasion in progression of ovarian carcinoma. Data regarding the role that the chemokine receptors play in the disease progression accumulated insofar strongly suggest that this family of proteins could be good therapeutic targets against ovarian carcinoma.
This project was generously supported by National Cancer Institute (grant # CA160917 to Maria Barbolina) and Ovarian Cancer Research Foundation Liz Tilberis Scholar Award (to Maria Barbolina).