Copper-mediated synthesis.pdf (425.26 kB)
Download fileCopper-mediated synthesis of N-alkenyl-α,β-unsaturated nitrones and their conversion to tri- and tetrasubstituted pyridines.
journal contribution
posted on 15.12.2016, 00:00 authored by D Kontokosta, DS Mueller, DL Mo, WH Pace, RA Simpson, LL AndersonA Chan-Lam reaction has been used to prepare N-alkenyl-α,β-unsaturated nitrones, which undergo a subsequent thermal rearrangement to the corresponding tri- and tetrasubstituted pyridines. The optimization and scope of these transformations is discussed. Initial mechanistic experiments suggest a reaction pathway involving oxygen transfer followed by cyclization.