BCNE FINAL (8) edited 10302012 final.pdf (277.23 kB)
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Current Issues in the Diagnosis and Management of Blood-Culture Negative Infective and Non-Infective Endocarditis

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journal contribution
posted on 06.12.2013, 00:00 authored by Anthi Katsouli, Malek G. Massad
Diagnosis and management of blood culture negative endocarditis constitute a formidable clinical challenge and a systemic approach is necessary for a successful outcome. Blood cultures are negative in endocarditis due mainly to preceding antibiotic administration or to fastidious slow-growing organisms. Less so, non-infective endocarditis as a paraneoplastic manifestation or may occur in association with autoimmune diseases. When the clinical diagnosis is contemplated and cultures and serologies are negative, histologic and molecular examination of the removed valve tissue may confirm the diagnosis. Treatment with antibiotics is often warranted and valve replacement remains appropriate for patients with heart failure or irreversible structural damage.


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NOTICE: This is the author’s version of a work that was accepted for publication in Annals of Thoracic Surgery. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Annals of Thoracic Surgery, Vol 95, Issue 4, 2013 DOI: 10.1016/j.athoracsur.2012.10.044







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