ijms-13-11012-v2.pdf (303.88 kB)
Download fileDamaged DNA Binding Protein 2 in Reactive Oxygen Species (ROS) Regulation and Premature Senescence
journal contribution
posted on 2013-12-05, 00:00 authored by Nilotpal Roy, Srilata Bagchi, Pradip RaychaudhuriPremature senescence induced by DNA damage or oncogene is a critical
mechanism of tumor suppression. Reactive oxygen species (ROS) have been implicated in
the induction of premature senescence response. Several pathological disorders such as
cancer, aging and age related neurological abnormalities have been linked to ROS
deregulation. Here, we discuss how Damaged DNA binding Protein-2 (DDB2), a
nucleotide excision repair protein, plays an important role in ROS regulation by
epigenetically repressing the antioxidant genes MnSOD and Catalase. We further revisit a
model in which DDB2 plays an instrumental role in DNA damage induced ROS
accumulation, ROS induced premature senescence and inhibition of skin tumorigenesis.