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Duration of observation required in detecting fasciculation potentials in amyotrophic lateral sclerosis using high-density surface EMG
journal contributionposted on 2013-12-06, 00:00 authored by Ping Zhou, Xiaoyan Li, Faezeh Jahanmiri-Nezhad, William Zev Rymer, Paul E. Barkhaus
Background: High-density surface electromyography (HD-SEMG) has recently emerged as a potentially useful tool in the evaluation of amyotrophic lateral sclerosis (ALS). This study addresses a practical constraint that arises when applying HD-SEMG for supporting the diagnosis of ALS; specifically, how long the surface EMG should be recorded before one can be confident that fasciculation potentials (FPs) are absent in a muscle being tested. Methods: HD-SEMG recordings of 29 muscles from 11 ALS patients were analyzed. We used the distribution of intervals between FPs, and estimated the observation duration needed to record from one to five FPs with a probability approaching unity. Such an approach was previously tested by Mills with a concentric needle electrode. Results: We found that the duration of recording was up to 70 s in order to record a single FP with a probability approaching unity. Increasing recording time to 2 minutes, the probability of recording five FPs approached approximately 0.95. Conclusions: HD-SEMG appears to be a suitable method for capturing FPs comparable to intramuscular needle EMG.
This study was supported by the National Institute on Disability and Rehabilitation Research of the U.S. Department of Education (Grant H133G 090093) and the National Institutes of Health (Grant 2R24HD050821). Dr. Barkhaus also acknowledges support in part from the Dolores and Carroll Olson Fund of the Greater Milwaukee Foundation
Publisher Statement© 2012 Zhou et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
CitationZhou P, Li XY, Jahanmiri-Nezhad F, Rymer WZ, Barkhaus PE. Duration of observation required in detecting fasciculation potentials in amyotrophic lateral sclerosis using high-density surface EMG. Journal of Neuroengineering and Rehabilitation. Oct 2012;9. DOI: 10.1186/1743-0003-9-78