Exercise intolerance in pulmonary hypertension: mechanism, evaluation and clinical implications.
journal contributionposted on 2017-05-09, 00:00 authored by Babu AS, Ross Arena, Myers J, Padmakumar R, Maiya AG, Cahalin LP, Waxman AB, Lavie CJ
Introduction: Exercise intolerance in pulmonary hypertension (PH) is a major factor affecting activities of daily living and quality of life. Evaluation strategies (i.e., non-invasive and invasive tests) are integral to providing a comprehensive assessment of clinical and functional status. Despite a growing body of literature on the clinical consequences of PH, there are limited studies discussing the contribution of various physiological systems to exercise intolerance in this patient population. Areas covered: This review, through a search of various databases, describes the physiological basis for exercise intolerance across the various PH etiologies, highlights the various exercise evaluation methods and discusses the rationale for exercise training amongst those diagnosed with PH. Expert commentary: With the growing importance of evaluating exercise capacity in PH (class 1, Level C recommendation), understanding why exercise performance is altered in PH is crucial. Thus, the further study is required for better quality evidence in this area.
Publisher StatementPost print version of article may differ from published version. This is an electronic version of an article published in Babu, A. S., Arena, R., Myers, J., Padmakumar, R., Maiya, A. G., Cahalin, L. P., Waxman, A. B. and Lavie, C. J. Exercise intolerance in pulmonary hypertension: mechanism, evaluation and clinical implications. Expert Review of Respiratory Medicine. 2016. 10(9): 979-990. 10.1080/17476348.2016.1191353. Expert Review of Respiratory Medicine is available online at: http://www.informaworld.com/smpp/ DOI: 10.1080/17476348.2016.1191353.
PublisherTaylor & Francis