Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by LAAR accepted manuscript.pdf (574.64 kB)
Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides
journal contributionposted on 2022-06-22, 16:29 authored by Richard J Doyle, Zane ElfessiZane Elfessi, Kevin Kolman
Acute, unintentional drug-related poisonings lead to an estimated 418,313 ED visits in 2014, according to the latest statistics from the Center for Disease Control and Prevention. While most of these were opiate-related poisonings, anticoagulant rodenticides were the most common cause of rodenticide-related poisoning in the United States. Many clinical syndromes and treatment algorithms have been described for patients with anticoagulant rodenticide poisoning. We report a case of an acute ingestion of two anticoagulant rodenticides and successful reversal of coagulation parameters using 4-factor prothrombin complex concentrate in a fixed-dose approach.
CitationDoyle, R. J., Elfessi, Z.Kolman, K. (2018). Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides. The American Journal of Emergency Medicine, 36(10), 1922.e3-1922.e4. https://doi.org/10.1016/j.ajem.2018.06.040
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HematologyPreventionRodenticidesBrodifacoumDifenacoumProthrombin complex concentrates4-HydroxycoumarinsAbdominal PainAgedAnticoagulantsBlood Coagulation DisordersBlood Coagulation FactorsDrug ContaminationDrug Dosage CalculationsHemorrhageHumansIllicit DrugsMaleSynthetic DrugsTreatment OutcomeVitamin KEmergency & Critical Care MedicineClinical Sciences