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Frame-shifted proteins of a given gene are unlikely to retain the same function

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journal contribution
posted on 28.04.2021, 17:05 by Alexander Mankin
In a recently published paper, Huang and coworkers claim that proteins translated in different reading frames from the same mRNA can have similar functions. This conclusion is possibly incorrect due to the possibility that the wild-type protein could still be expressed.

Funding

Exploiting antibiotics to understand the ribosome and translation

National Institute of General Medical Sciences

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Control of translation by the nascent protein after its full synthesis and release

Directorate for Biological Sciences

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History

Citation

Mankin, A. S. (2020). Frame-shifted proteins of a given gene are unlikely to retain the same function. RNA, 26(10), 1301-1302. https://doi.org/10.1261/rna.076398.120

Publisher

Cold Spring Harbor Laboratory

Language

en

issn

1355-8382