Functional Loss in the Magnocellular and Parvocellular Pathways in Patients with Optic Neuritis
journal contributionposted on 2012-06-25, 00:00 authored by Dingcai Cao, Andrew J. Zele, Joel Pokorny, David Y. Lee, Leonard V. Messner, Christopher Diehl, Susan Ksiazek
Purpose: To evaluate contrast threshold and contrast gain in patients with optic neuritis under conditions designed to favor mediation by either the inferred Magnocellular (MC-) or Parvocellular (PC-) pathway. Methods: Achromatic and chromatic contrast discrimination was measured in 11 patients with unilateral or bilateral optic neuritis and 18 age-matched controls with normal vision, using achromatic steady-pedestal and pulsed-pedestal paradigms to bias performance toward the MC- or PC- pathway respectively. Additionally, L-M chromatic discrimination at equiluminance was evaluated using the steady-pedestal paradigm. . A physiologically plausible model could describe the data with parameters accounting for contrast gain and contrast sensitivity in the inferred MC- or PC- pathway. The fitted parameters from the affected eye by optic neuritis were compared with those from the normal eyes using Generalized Estimation Equation (GEE) models that can account for within-subject correlations. Results: Compared with normal eyes, the affected eyes had significantly higher saturation parameters when measured with both the achromatic pulsed-pedestal paradigm [GEE: β(se) = 0.35(0.06), p < 0.001] and the chromatic discrimination paradigm [β(se) = 0.18(0.08), p = 0.015], suggesting contrast gain in the inferred PCpathway is reduced; the affected eyes also had reduced absolute sensitivity in the inferred MC-pathway measured with the achromatic steady-pedestal paradigm [β(se) = 0.12 (0.04), p = 0.005]. Conclusion: Optic neuritis produced large sensitivity loss mediated by the MCpathway and contrast gain losses in the inferred PC- pathway. A clinical framework is presented for interpreting contrast sensitivity and gain loss to chromatic and achromatic stimuli in terms of retinal and post-retinogeniculate loci contributions to detection and discrimination.
National Eye Institute grants R01EY019651 (D. Cao) and by Australia Research Council Discovery Projects DP1096354 (AJZ) supported this work.
Publisher StatementPost print version of article may differ from published version. The definitive version is available through Association for Research in Vision and Ophthalmology at doi: 10.1167/iovs.11-7644
PublisherAssociation for Research in Vision and Ophthalmology