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Gustatory insular cortex, aversive taste memory and taste neophobia

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journal contribution
posted on 28.01.2016, 00:00 authored by J.-Y. Lin, J. Arthurs, S. Reilly
Prior research indicates a role for the gustatory insular cortex (GC) in taste neophobia. Rats with lesions of the GC show much weaker avoidance to a novel and potentially dangerous taste than do neurologically intact animals. The current study used the retention of conditioned taste aversion (CTA) as a tool to determine whether the GC modulates neophobia by processing taste novelty or taste danger. The results show that GC lesions attenuate CTA retention (Experiment 1) and impair taste neophobia (Experiment 2). Given that normal CTA retention does not involve the processing of taste novelty, the pattern of results suggests that the GC is involved in taste neophobia via its function in processing the danger conveyed by a taste stimulus.

Funding

This work was supported by grants DC06456 from the National Institute of Deafness and Other Communication Disorders.

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Publisher Statement

This is the author’s version of a work that was accepted for publication in Neurobiology of Learning and Memory. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurobiology of Learning and Memory, 2015. 119: 77-84. DOI: 10.1016/j.nlm.2015.01.005.

Publisher

Elsevier Inc.

issn

1074-7427

Issue date

01/03/2015

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