Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.
journal contributionposted on 2016-05-09, 00:00 authored by WF Li, J Wang, JJ Zhang, X Song, CF Ku, J Zou, JX Li, LJ Rong, LT Pan, HJ Zhang
Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).