IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis
journal contributionposted on 2013-10-22, 00:00 authored by Charlotte Hvaring, Snezana Vujicic, Jan O. Aasly, Douglas L. Feinstein, Linda R. White, Anne I. Boullerne
This study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal rather than the result of ingress from serum. Two correlations during relapse: between CSF level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.
This work was supported by the National Multiple Sclerosis Society, USA (PP1366 to A.I.B.), and a scholarship from the Norwegian University of Science and Technology (C.H.).
Publisher StatementNOTICE: This is the author’s version of a work that was accepted for publication in Journal of Neuroimmunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroimmunology, Issue 1-2, 2013 DOI: 10.1016/j.jneuroim.2012.12.011