INDIGO_Manuscript_Resubmitted December 2012.pdf (199 kB)
Download fileIgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis
journal contribution
posted on 2013-10-22, 00:00 authored by Charlotte Hvaring, Snezana Vujicic, Jan O. Aasly, Douglas L. Feinstein, Linda R. White, Anne I. BoullerneThis study has established the presence of IgM against S-nitrosylated proteins in
cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope
(anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in
CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence
from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal
rather than the result of ingress from serum. Two correlations during relapse: between CSF
level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum
anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.