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Intravenous Application of a Primary Sevoflurane Metabolite Improves Outcome in Murine Septic Peritonitis: First Results

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posted on 2014-01-03, 00:00 authored by Inge K. Herrmann, Maricela Castellon, David E. Schwartz, Melanie Hasler, Martin Urner, Guochang Hu, Richard D. Minshall, Beatrice Beck-Schimmer
Volatile anesthetics are known to have immunomodulatory effects in conditions of organ injury. A recent study in an experimental sepsis model has shown remarkably improved survival when mice were exposed to volatile anesthetics. In the present study, we show that hexafluoroisopropanol - a water-soluble primary sevoflurane metabolite - has beneficial effects on the overall survival in a murine model of cecal ligation and puncture. Seven-day survival as well as tissue damage markers including transaminases and high mobility group box protein-1 were assessed as measures of end organ damage. In animals undergoing cecal ligation and puncture procedure hexafluoroisopropanol conditioning - but not late postconditioning 24 hours after sepsis induction - significantly increased survival rate (17% vs. 77%, p = 0.037) and attenuated secretion of organ damage markers. This study shows survival benefits by administration of the metabolite of a volatile anesthetic. If successfully translated, hexafluoroisopropanol might offer interesting therapeutic opportunities in the future treatment of abdominal sepsis.


Funding came from the Swiss National Science Foundation, Berne, Switzerland, Grant No. 320030_141216; National Institutes of Health, Bethesda, MD, USA, NIH P01 HL60678 and R01 HL71626; Emdo Foundation, Zurich, Switzerland.


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© 2013 Herrmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. © 2013 by Name of Public Library of Science, PLos ONE


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