File(s) stored somewhere else

Please note: Linked content is NOT stored on University of Illinois at Chicago and we can't guarantee its availability, quality, security or accept any liability.

Label-free microfluidic sorting of microparticles

journal contribution
posted on 07.07.2021, 20:37 by Jian ZhouJian Zhou, P Mukherjee, H Gao, Q Luan, Ian PapautskyIan Papautsky
Massive growth of the microfluidics field has triggered numerous advances in focusing, separating, ordering, concentrating, and mixing of microparticles. Microfluidic systems capable of performing these functions are rapidly finding applications in industrial, environmental, and biomedical fields. Passive and label-free methods are one of the major categories of such systems that have received enormous attention owing to device operational simplicity and low costs. With new platforms continuously being proposed, our aim here is to provide an updated overview of the state of the art for passive label-free microparticle separation, with emphasis on performance and operational conditions. In addition to the now common separation approaches using Newtonian flows, such as deterministic lateral displacement, pinched flow fractionation, cross-flow filtration, hydrodynamic filtration, and inertial microfluidics, we also discuss separation approaches using non-Newtonian, viscoelastic flow. We then highlight the newly emerging approach based on shear-induced diffusion, which enables direct processing of complex samples such as untreated whole blood. Finally, we hope that an improved understanding of label-free passive sorting approaches can lead to sophisticated and useful platforms toward automation in industrial, environmental, and biomedical fields.

Funding

Phase II IUCRC at University of Illinois at Chicago: Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM)

Directorate for Engineering

Find out more...

History

Citation

Zhou, J., Mukherjee, P., Gao, H., Luan, Q.Papautsky, I. (2019). Label-free microfluidic sorting of microparticles. APL Bioengineering, 3(4), 041504-. https://doi.org/10.1063/1.5120501

Publisher

AIP Publishing

Language

en

issn

2473-2877

Usage metrics

Read the peer-reviewed publication

Categories

Licence

Exports