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Metabolic Syndrome Predicts All-Cause Mortality in Persons with Human Immunodeficiency Virus

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journal contribution
posted on 13.08.2015, 00:00 by Olamide D. Jarrett, Christine A. Wanke, Robin Ruthazer, Ioana Bica, Rita Isaac, Tamsin A. Knox
We examined the association between metabolic syndrome (MS) and its individual defining criteria on all-cause mortality in human immunodeficiency virus (HIV)-infected persons. We used data from 567 HIV-infected participants of the Nutrition for Healthy Living study with study visits between 9/1/2000 and 1/31/2004 and determined mortality through 12/31/2006. MS was defined using modified National Cholesterol Education Program guidelines. Cox proportional hazards for all-cause mortality were estimated for baseline MS status and for its individual defining criteria. There were 83 deaths with median follow-up of 63 months. Baseline characteristics associated with increased risk of mortality were: older age in years (univariate hazard ratio [HR] 1.04, p < 0.01), current smoking (HR 1.99, p = 0.02), current heroin use (HR 1.97, p = 0.02), living in poverty (HR 2.0, p < 0.01), higher mean HIV viral load (HR 1.81, p < 0.01), and having a BMI < 18 (HR 5.84, p < 0.01). For MS and its criteria, only low HDL was associated with increased risk of mortality on univariate analysis (HR 1.84, p = 0.01). However, metabolic syndrome (adjusted HR 2.31, p = 0.02) and high triglycerides (adjusted HR 3.97, p < 0.01) were significantly associated with mortality beyond 36 months follow-up. MS, low HDL, and high triglycerides are associated with an increased risk of mortality in HIV-infected individuals.


Financial support for this study was received from National Institutes of Health (T32A1007438-14, P01DK45734, 1P30DA13868, 1K24 A1055293-05, and UL1RR025752-01) and Lifespan/Tufts/Brown Center for AIDS Research (1P30A142853-106637).


Publisher Statement

This is a copy of an article published in the AIDS Patient Care and STDs © 2013 Copyright Mary Ann Liebert, Inc.; AIDS Patient Care and STDs is available online at: http://www.liebertonline.com.


Mary Ann Liebert





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