Mitochondrial Small RNAs that are Up-Regulated in Hippocampus during Olfactory Discrimination Training in Mice
journal contribution
posted on 2012-08-20, 00:00 authored by Neil R. Smalheiser, Giovanni Lugli, Jyothi Thimmapuram, Edwin H. Cook, John LarsonAdult mice were trained to execute a nose-poke in a port containing one of two
simultaneously present odors in order to obtain a reward. Hippocampus RNA of trained
mice vs. controls was subjected to Illumina deep sequencing. Two mitochondrial RNAs
(a tRNA and Mt-1) gave rise to 25-30-nt. small RNAs that showed a dramatic and
specific increase with training (>50-fold relative to controls). Mt-1 is encoded within the termination association sequence (TAS) of the mitochondrial DNA control region. Small
RNAs may link behavioral plasticity to protein synthesis and replication of mitochondria to support dendritic growth, spine stabilization, and synapse formation.
Funding
Work was supported by the Jean Young and Walden W. Shaw Foundation, NIH (Autism Center of Excellence P50 HD055751), and the Stanley Medical Research Institute.
History
Publisher Statement
NOTICE: this is the author’s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, Volume 11, Issue 6, November 2011. DOI: 10.1016/j.mito.2011.08.014Publisher
ElsevierLanguage
- en_US
issn
1567-7249Issue date
2011-11-01Usage metrics
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