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Neural crossroads in the hematopoietic stem cell niche

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journal contribution
posted on 14.01.2019, 00:00 by Sobhika Agarwala, Owen J. Tamplin
The hematopoietic stem cell (HSC) niche supports steady-state hematopoiesis and responds to changing needs during stress and disease. The nervous system is an important regulator of the niche, and its influence is established early in development when stem cells are specified. Most research has focused on direct innervation of the niche, however recent findings show there are different modes of neural control, including globally by the central nervous system (CNS) and hormone release, locally by neural crest-derived mesenchymal stem cells, and intrinsically by hematopoietic cells that express neural receptors and neurotransmitters. Dysregulation between neural and hematopoietic systems can contribute to disease, however new therapeutic opportunities may be found among neuroregulator drugs repurposed to support hematopoiesis.

Funding

This work was supported by a Junior Faculty Scholar Award from the American Society of Hematology (ASH), and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health under award number K01DK103908.

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Citation

Agarwala, S., & Tamplin, O. J. (2018). Neural Crossroads in the Hematopoietic Stem Cell Niche. Trends in Cell Biology, 28(12), 987-998. doi:10.1016/j.tcb.2018.05.003

Publisher

Elsevier

Language

en_US

issn

0962-8924

Issue date

28/12/2018

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