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Of mice and men: neurogenesis, cognition, and Alzheimer's disease

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posted on 2013-11-21, 00:00 authored by Orly Lazarov, Robert A. Marr
Neural stem cells are maintained in the subgranular layer of the dentate gyrus and in the subventricular zone in the adult mammalian brain throughout life. Neurogenesis is continuous, but its extent is tightly regulated by environmental factors, behavior, hormonal state, age, and brain health. Increasing evidence supports a role for new neurons in cognitive function in rodents. Recent evidence delineates significant similarities and differences between adult neurogenesis in rodents and humans. Being context-dependent, neurogenesis in the human brain might be manifested differently than in the rodent brain. Decline in neurogenesis may play a role in cognitive deterioration, leading to the development of progressive learning and memory disorders, such as Alzheimer's disease. This review discusses the different observations concerning neurogenesis in the rodent and human brain, and their functional implications for the healthy and diseased brain.


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Copyright © 2013 Lazarov and Marr. This is an open-access article dis- tributed under the terms of the Creative Commons Attribution License(CCBY). The use,distribution or reproduction in other forums is permitted, provided the original author(s)or licens or are cred- ited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permit- ted which does not comply with these terms. This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.







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