Oral clindamycin causing acute cholestatic hepatitis.pdf (1.96 MB)
Download fileOral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
journal contribution
posted on 12.09.2016, 00:00 authored by Harsha Moole, Zohair Ahmed, Nibha Saxena, Srinivas R. Puli, Sonu DhillonClindamycin is a lincosamide antibiotic active against most of the anaerobes, protozoans, and Gram-positive
bacteria, including community-acquired methicillin-resistant Staphylococcus aureus. Its use has increased
greatly in the recent past due to wide spectrum of activity and good bioavailability in oral form. Close to 20%
of the patients taking clindamycin experience diarrhea as the most common side effect. Hepatotoxicity is
a rare side effect. Systemic clindamycin therapy has been linked to two forms of hepatotoxicity: transient
serum aminotransferase elevation and an acute idiosyncratic liver injury that occurs 1 3 weeks after starting
therapy. This article is a case report of oral clindamycin induced acute symptomatic cholestatic hepatitis and a
brief review of the topic.