Boodram_etal_PLoSONE_2022.pdf (813.45 kB)
Download file

People who inject drugs in metropolitan Chicago: A meta-analysis of data from 1997-2017 to inform interventions and computational modeling toward hepatitis C microelimination

Download (813.45 kB)
journal contribution
posted on 15.11.2022, 22:38 authored by Basmattee BoodramBasmattee Boodram, Mary Mackesy-AmitiMary Mackesy-Amiti, Aditya Khanna, Bryan Brickman, Harel Dahari, Jonathan Ozik
Progress toward hepatitis C virus (HCV) elimination in the United States is not on track to meet targets set by the World Health Organization, as the opioid crisis continues to drive both injection drug use and increasing HCV incidence. A pragmatic approach to achieving this is using a microelimination approach of focusing on high-risk populations such as people who inject drugs (PWID). Computational models are useful in understanding the complex interplay of individual, social, and structural level factors that might alter HCV incidence, prevalence, transmission, and treatment uptake to achieve HCV microelimination. However, these models need to be informed with realistic sociodemographic, risk behavior and network estimates on PWID. We conducted a meta-analysis of research studies spanning 20 years of research and interventions with PWID in metropolitan Chicago to produce parameters for a synthetic population for realistic computational models (e.g., agent-based models). We then fit an exponential random graph model (ERGM) using the network estimates from the meta-analysis in order to develop the network component of the synthetic population.

Funding

Contextual Risk Factors for Hepatitis C Among Young Persons Who inject Drugs | Funder: National Institutes of Health (National Institute on Drug Abuse) | Grant ID: R01DA043484

Computational Discovery of Effective Hepatitis C intervention Strategies | Funder: Loyola University Chicago | Grant ID: R01GM121600

History

Citation

Boodram, B., Mackesy-Amiti, M. E., Khanna, A., Brickman, B., Dahari, H.Ozik, J. (2022). People who inject drugs in metropolitan Chicago: A meta-analysis of data from 1997-2017 to inform interventions and computational modeling toward hepatitis C microelimination. PLoS ONE, 17(1), e0248850-. https://doi.org/10.1371/journal.pone.0248850

Publisher

Public Library of Science (PLoS)

Language

en

issn

1932-6203